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Inflammation: improving understanding to prevent or ameliorate kidney diseases

Sheila Marques Fernandes1, Mirian Watanabe1,2, Maria de Fátima Fernandes Vattimo1 [ + show more ]

J Venom Anim Toxins incl Trop Dis, 2021 27: e20200162
Received: 01 December 2020 | Accepted: 12 de April 2021 | Published online: 18 October 2021
Collection: Inflammation: from bench to bedside
https://doi.org/10.1590/1678-9199-JVATITD-2020-0162

Abstract

Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered protective, an uncontrolled inflammation may evolve to tissue damage, leading to chronic inflammatory diseases. Inflammation can be considered the major factor involved in the pathological progression of acute and chronic kidney diseases. Functional characteristics of this organ increase its vulnerability to developing various forms of injuries, including acute kidney injury (AKI) and chronic kidney disease (CKD). In view of translational research, several discoveries should be considered regarding the pathogenesis of the inflammatory process, which results in the validation of biomarkers for early detection of kidney diseases. Biomarkers enable the identification of proinflammatory mediators in kidney affections, based on laboratory research applied to clinical practice. Some inflammatory molecules can be useful biomarkers for the detection and diagnosis of kidney diseases, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin 18.

 

Keywords: Inflammation; Acute kidney injury; Kidney diseases; Biomarkers.

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